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  • KH-Glucan


KH-Glucan is a yeast β-glucan purified from a fermented broth with Aureobasidium pullulans. KH-Glucan shows not only physical moisturizing effect and soft texture by film-forming on the skin but also anti-inflammatory effect by inhibition of expression of inflammatory cytokines. Also, KH-Glucan protects skin against microbials and viruses by increase of secretion of interleukin-2, 12 and interferon-gamma.

Items KH-Glucan other Glucans
Origin Secreted polysaccharide from yeast Yeast cell wall extract Mushroom extract
structure β-1,3/1,6 Mixed structure of β-1,3/1,4/1,6 or α-
Appearance Colorless liquid Slightly yellow and specific odor
Water soluble Soluble Slightly soluble
Purity More than 80% 30-50%
Application Food, cosmetics, medicine Food, cosmetics

Increased secretion of Interleukin-2, Interleukin-12, Interferon-gamma and TNF-α by KH-Glucan

Chemical structure of KH-Glucan

Inhibition of Expression of inflammatory cytokines by KH-Glucan

  • Relative TNFa mRNA expression
  • Relative IL-1a mRNA expression
  • Relative IL-1b mRNA expression
  • Relative IL-6 mRNA expression
Description Colorless liquid
Law Structure β-1,3/1,6 glucan
Odor Typical
pH(neat) 6.0 – 8.0
Dry Residue ≥0.3%
Purity Heavy Metals Arsenic ≤20ppm ≤2ppm
Molecular weight 1MDa – 3MDa
Total Bacterial Count ≤100 cfu/g
Molds & Yeast ≤10 cfu/g
  • Skin Moisturizing effect by application
    of KH-Glucan (Corneometer)
  • Erythma reduction effect by treatment of
    KH-Glucan after UV-irradiation